BDBM50440736 CHEMBL2431088

SMILES Cc1noc(N)c1-c1ccccc1

InChI Key InChIKey=ZCTBUBMRXYVEHX-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50440736   

TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440736(CHEMBL2431088)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50440736(CHEMBL2431088)
Affinity DataEC50:  9.70E+3nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50440736(CHEMBL2431088)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440736(CHEMBL2431088)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of BRD4 bromodomain-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440736(CHEMBL2431088)
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of BRD4 (unknown origin) expressed in Escherichia coli BL21 (DE3) using [Lys(Ac)5/8/12/16]-histone H4 (1 to 21residues)-GGK as substrate i...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440736(CHEMBL2431088)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotinylated ligand incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed