BDBM50436850 CERITINIB::CHEMBL2403108::LDK378::US10053458, Comparative Example 2::US10618884, Example 16::US9809572, Example 16
SMILES CC(C)Oc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1
InChI Key InChIKey=VERWOWGGCGHDQE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 190 hits for monomerid = 50436850
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of ALK (unknown origin) transfected in mouse BA/F3 cellsMore data for this Ligand-Target Pair
3D Structure (crystal)TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1 [547-977](Human)
University of Washington
University of Washington
Affinity DataIC50: 3.70E+3nMpH: 7.5Assay Description:Inhibitors (initial concentration 10 or 60 μM, three-fold serial dilutions) were incubated with IRE1α* in cleavage buffer (20 mM HEPES at p...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of purified ALK (unknown origin) after 60 mins by ELISA kinase assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of wild type ALK (unknown origin) by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 93nMAssay Description:Inhibition of insulin receptor (unknown origin) by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of wild type ALK (unknown origin) after 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) after 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of ROS1 (unknown origin) using peptide as substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of ROCK2 (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of ABL (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of PDGFRalpha (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 610nMAssay Description:Inhibition of JAK2 (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of RET (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of FLT3 (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetTestis-specific serine/threonine-protein kinase 1(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of STK22D (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of IGF1 receptor (unknown origin) after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of insulin receptor (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ALK (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ZAP-70(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of ZAP70 (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 7.92E+3nMAssay Description:Inhibition of JAK3 (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3.73E+3nMAssay Description:Inhibition of JAK1 (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3.36E+3nMAssay Description:Inhibition of BTK (unknown origin) after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.17E+3nMAssay Description:Inhibition of cMET (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3.05E+3nMAssay Description:Inhibition of SYK (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 2.24E+3nMAssay Description:Inhibition of MKNK2 (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of EML4-fused ALK (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of TEL-fused RET (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 2.16E+3nMAssay Description:Inhibition of TEL-fused JAK2 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of TEL-fused TRKB (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of TEL-fused MET (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of TEL-fused IGF1 receptor (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of TEL-fused insulin receptor (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 142nMAssay Description:Inhibition of TEL-fused ROS (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of TEL-fused ALK (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 2(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PAK2 (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetTranscription factor ETV6(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of wild-type TEL (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3.14E+3nMAssay Description:Inhibition of TEL-fused FLT3 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Human)
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 2.73E+3nMAssay Description:Inhibition of TEL-fused TRKA (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor [L1196M](Human)
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of wild-type ALK (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of wild type ALK (unknown origin) using TK as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of insulin receptor kinase (unknown origin) using TK as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair