BDBM50435378 CHEMBL1586371

SMILES O=S(=O)(N1CCCCC1)c1ccc(NC(=S)NCc2cccnc2)cc1

InChI Key InChIKey=NIADLWNDYLCGNO-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50435378   

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435378(CHEMBL1586371)
Affinity DataIC50: 7nMAssay Description:Inhibition of Nampt (unknown origin) using NAM/PRPP as substrate preincubated for 15 mins measured after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide phosphoribosyltransferase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435378(CHEMBL1586371)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of human recombinant NAMPT using NAM as substrate preincubated for 5 mins followed by substrate addition measured after 15 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50435378(CHEMBL1586371)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant HDAC1 (1 to 482 residues) expressed in Baculovirus using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435378(CHEMBL1586371)
Affinity DataIC50: 61nMAssay Description:Inhibition of NAMPT (unknown origin) using NAM as substrate preincubated for 5 mins followed by substrate addition measured after 15 mins in presence...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)