BDBM50433476 CHEMBL2381116

SMILES COc1ccc2CN(C(=O)c2c1)c1nc(cs1)C(=O)Nc1cnccc1N1CCNCC1

InChI Key InChIKey=KLJVDMAOKMSBQX-UHFFFAOYSA-N

Data  21 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50433476   

TargetMitogen-activated protein kinase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ERK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataEC50:  30nMAssay Description:Inhibition of CHK1 in human U2OS cells assessed as phosphorylation of H2AX after 2 hrs by FITC/propidium iodide staining-based immunofluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 3.00E+4nMAssay Description:Time-dependent inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 30 mins prior to substrate addition m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 3.00E+4nMAssay Description:Time-dependent inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate incubated for 30 mins prior to substrate addition measur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human AKT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type IV(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human CAMK4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human CHK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CSNK1DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTestis-specific serine/threonine-protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of human TSSK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human IKKBMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human IRAK4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human METMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human MST2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of human NEK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human PLK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human RSK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed