BDBM50433375 CHEMBL472879::GNF-Pf-359

SMILES Cc1nc(nc(NCCc2ccccc2)c1Cl)-c1ccccn1

InChI Key InChIKey=HIUOABSWQSUEGK-UHFFFAOYSA-N

Data  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50433375   

TargetMethionine aminopeptidase 1(Human)
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50433375(GNF-Pf-359 | CHEMBL472879)
Affinity DataEC50:  190nMAssay Description:Inhibition of human methionine aminopeptidase 1 in presence of Co2+More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 1(Human)
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50433375(GNF-Pf-359 | CHEMBL472879)
Affinity DataEC50:  710nMAssay Description:Inhibition of human methionine aminopeptidase 1 in presence of Zn2+More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 1(Human)
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50433375(GNF-Pf-359 | CHEMBL472879)
Affinity DataEC50:  1.50E+4nMAssay Description:Inhibition of human methionine aminopeptidase 1 in presence of Mn2+More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMicrotubule-associated protein 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50433375(GNF-Pf-359 | CHEMBL472879)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 1(Human)
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50433375(GNF-Pf-359 | CHEMBL472879)
Affinity DataIC50: 860nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 1(Human)
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50433375(GNF-Pf-359 | CHEMBL472879)
Affinity DataIC50: 700nMAssay Description:Inhibition of HuMetAP1 using Met-Pro-pNA as substrate by spectrophotometer based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMethionine aminopeptidase 2(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50433375(GNF-Pf-359 | CHEMBL472879)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of HuMetAP2 using Met-Pro-pNA as substrate by spectrophotometer based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed