BDBM50421688 CHEMBL5267938

SMILES ONC(=O)[C@@H](CCCNC(=O)CCCNC(=O)c1cccc(c1)C(=O)NCCCC(=O)NCCC[C@@H](NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1)C(=O)NO)NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1

InChI Key InChIKey=STNUPCVMYSYFEG-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50421688   

LigandPNGBDBM50421688(CHEMBL5267938)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant ADAM8 using PepDAB13 as substrate preincubated with enzyme for 45 mins followed by substrate addition and measured fo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50421688(CHEMBL5267938)
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant ADAM17 (unknown origin) using PepDAB13 as substrate preincubated with enzyme for 45 mins followed by substrate addition and...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50421688(CHEMBL5267938)
Affinity DataIC50: 4.15E+5nMAssay Description:Inhibition of MMP-1 in human Rheumatoid Synovial fibroblasts using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme...More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50421688(CHEMBL5267938)
Affinity DataIC50: 4.66E+3nMAssay Description:Inhibition of human recombinant MMP-2 expressed in mouse cells using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzy...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50421688(CHEMBL5267938)
Affinity DataIC50: 3.32E+3nMAssay Description:Inhibition of human recombinant MMP-9 expressed in CHO cells using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMacrophage metalloelastase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50421688(CHEMBL5267938)
Affinity DataIC50: 242nMAssay Description:Inhibition of human recombinant MMP12 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme for 3 hrs followed by ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetMatrix metalloproteinase-14(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50421688(CHEMBL5267938)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme for 3...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50421688(CHEMBL5267938)
Affinity DataIC50: 3.06E+4nMAssay Description:Inhibition of human recombinant ADAM10 expressed in baculovorus-infected Sf21 cells using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate p...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50421688(CHEMBL5267938)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of ADAM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of CD23 shedding by measuring reduction of soluble CD23 release...More data for this Ligand-Target Pair
In DepthDetails
PubMed