BDBM50416550 CHEMBL5274121

SMILES OC(=O)\C=C\C(=O)NNC(=O)c1cccnc1

InChI Key InChIKey=LIHXFKSRELDIPD-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50416550   

TargetAlpha-ketoglutarate-dependent dioxygenase AlkB(Escherichia coli (strain K12))
University College London

Curated by ChEMBL
LigandPNGBDBM50416550(CHEMBL5274121)
Affinity DataIC50: 1.69E+5nMAssay Description:Inhibition of Escherichia coli AlkB using 15-mer m1A-ssDNA as substrate incubated for 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50416550(CHEMBL5274121)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of human full length FTO expressed in Escherichia coli BL21 (DE3) Rosetta T1R cells using 3-methylthymidine as substrate incubated for 1 h...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetDNA oxidative demethylase ALKBH2(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50416550(CHEMBL5274121)
Affinity DataIC50: 1.52E+5nMAssay Description:Inhibition of human ALKBH2 (56 to 258 residues) expressed in Escherichia coli BL21 (DE3) cells using 15-mer m1A-ssDNA as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase alkB homolog 3(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50416550(CHEMBL5274121)
Affinity DataIC50: 1.15E+5nMAssay Description:Inhibition of N-terminal His-tagged human ALKBH3 (1 to 286 residues) using m6A-ssDNA as substrate incubated for 30 mins by MALDI-TOF-MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRNA demethylase ALKBH5(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50416550(CHEMBL5274121)
Affinity DataIC50: 1.68E+5nMAssay Description:Inhibition of human ALKBH5 expressed in Escherichia coli BL21 (DE3) Rosetta T1R cells using 5-mer m6A-ssRNA as substrate incubated for 30 mins by HPL...More data for this Ligand-Target Pair
In DepthDetails
PubMed