BDBM50402409 CHEMBL2208034

SMILES O=C(Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1)[C@H]1CCCN1

InChI Key InChIKey=ISOCDPQFIXDIMS-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50402409   

LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 911nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 484nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 125nMAssay Description:Inhibition of PDGFRBMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 226nMAssay Description:Inhibition of c-KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 314nMAssay Description:Inhibition of P70S6KMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 555nMAssay Description:Inhibition of FLT4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 547nMAssay Description:Inhibition of PDGFRAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 348nMAssay Description:Inhibition of TYK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 375nMAssay Description:Inhibition of IKKbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 140nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 370nMAssay Description:Inhibition of MLK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 134nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 695nMAssay Description:Inhibition of JAK2 in HEL 92.1.7 cells assessed as inhibition of STAT3 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 386nMAssay Description:Inhibition of JAK2 in HEL 92.1.7 cells assessed as inhibition of STAT1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 214nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed