BDBM50402224 CHEMBL2204739

SMILES CC(C)CC(CC(C)C)NC(=O)[C@@H]1CNC[C@@H](C1)N1CC(=O)N(CC1(C)C)c1ccccc1Cl

InChI Key InChIKey=VVEBLTKFUFYNOR-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50402224   

TargetRenin(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50402224(CHEMBL2204739)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of trypsin-activated human recombinant renin using (Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg) as substrate i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Crab-eating macaque)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50402224(CHEMBL2204739)
Affinity DataIC50: 10nMAssay Description:Inhibition of cynomolgus monkey plasma renin assessed as angiotensin 1 level after 60 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Crab-eating macaque)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50402224(CHEMBL2204739)
Affinity DataIC50: 10nMAssay Description:Inhibition of renin in cynomolgus monkey plasma after 60 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50402224(CHEMBL2204739)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg as substrate incubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)