BDBM50401285 CHEMBL2204532

SMILES CN(c1ccc(F)c(NC(=O)c2cccc(OC(C)(C)C#N)c2Cl)c1)c1ccc2nc(NC(=O)C3CC3)sc2n1

InChI Key InChIKey=BSBQPLUISHJULY-UHFFFAOYSA-N

Data  27 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50401285   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of IKKbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of VEGFR2 in HUVEC assessed as reduction of VGF-stimulated cell proliferation after 5 daysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 69nMAssay Description:Inhibition of wild type human BRAF (445 to 726) expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 23nMAssay Description:Inhibition of c-RAFMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 86nMAssay Description:Inhibition of FGFR3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 43nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 91nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 840nMAssay Description:Inhibition of TIE2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 430nMAssay Description:Inhibition of c-KitMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 130nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase I isoform delta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CK1deltaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 45nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MEKK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of aurora BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed