BDBM50399676 CHEMBL2178352::US9096601, 8-26

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n(C4CCCC4)c3n2)cc1

InChI Key InChIKey=QPOURHROVVCOHC-UHFFFAOYSA-N

Data  45 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 46 hits for monomerid = 50399676   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 290nMAssay Description:Inhibition of human recombinant SRC by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 5(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant MK5 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant MK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant JNK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human recombinant JAK3 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human recombinant JAK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human recombinant JAK1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant IRAK4 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GSK3beta by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant ERK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCOUP transcription factor 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant COT1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine--tRNA ligase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 720nMAssay Description:Inhibition of human recombinant SYK by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human recombinant MNK1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant MST1R by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of human recombinant MET by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant KIT by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant INSR by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant IGF1R by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant ERBB4 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant ERBB2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant EGFR by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human recombinant ALK by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CDK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant VEGFR2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor [L858R](Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 0.400nMAssay Description:The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [T790M,L858R](Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1nMAssay Description:The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 7nMAssay Description:The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataKd:  0.600nMAssay Description:Binding affinity to wild type EGFR by KINOMEscan kinase binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 400nMAssay Description:Inhibition of EGFR in human NCI-H1975 cells assessed as reduction in ERK phosphorylation incubated for 8 hrs by Western blotting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 400nMAssay Description:Inhibition of EGFR in human NCI-H1975 cells assessed as reduction in AKT phosphorylation incubated for 8 hrs by Western blotting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProtein kinase C alpha type(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human recombinant PKCalpha by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant EGFR by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 12(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant p38gamma by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 230nMAssay Description:Inhibition of human recombinant p38alpha by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase WNK1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant WNK1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1nMAssay Description:The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human recombinant TYK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant ROCK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PLK1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PKN2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human recombinant PKN1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human recombinant PKCtheta by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PKBalpha by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PIM2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PDK1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human recombinant MNK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed