BDBM50395274 CHEMBL1235213

SMILES CCOc1ccc(Nc2c(C)c(N[C@H]3CCCNC3)nc3ccnn23)cc1

InChI Key InChIKey=WJOUGMPFYANZMI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50395274   

TargetMAP kinase-activated protein kinase 2(Mouse)
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MAPKAP-K2 in mouse whole blood assessed as inhibition of LPS-induced TNFalpha production by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of MAPKAP-K2 in human whole blood assessed as inhibition of LPS-induced TNFalpha production by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of human MAPKAP-K2 in THP1 cells assessed as inhibition of LPS-induced TNFalpha production incubated 1 hr prior to LPS challenge measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CHK2 by cyclex assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human CHK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of CDK2 after 60 mins using [33P]-gamma-ATP by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50: 130nMAssay Description:Inhibition of MAPKAP-K2 using KKLNRTLSVA as substrate and [33P]-gamma-ATP after 30 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed