BDBM50392531 CHEMBL407632

SMILES CCOc1cc(OC)ccc1C1=N[C@H]([C@H](N1C(=O)N1CCN(CCO)CC1)c1ccc(Br)cc1)c1ccc(Br)cc1

InChI Key InChIKey=PVRYEWOXWGDQHA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50392531   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50392531(CHEMBL407632)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human GST-tagged MDM2 assessed as inhibition of binding to full length p53More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50392531(CHEMBL407632)
Affinity DataIC50: 140nMAssay Description:Binding affinity to MDM2 (unknown origin) expressed in Escherichia coli BL21(DE3) after 30 mins by fluorescence polarization assay in presence of P4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50392531(CHEMBL407632)
Affinity DataIC50: 140nMAssay Description:Inhibition of MDM2 binding to p53More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50392531(CHEMBL407632)
Affinity DataIC50: 140nMAssay Description:Binding affinity to MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2016
Entry Details Article
PubMed