BDBM50391814 CHEMBL2146901

SMILES Cc1cc2c(cc1-n1nnc3cc(ccc13)C(O)=O)C(C)(C)CCC2(C)C

InChI Key InChIKey=QSRQAKVNYDAVIT-UHFFFAOYSA-N

Data  1 IC50  3 Kd  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50391814   

TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50391814(CHEMBL2146901)
Affinity DataEC50:  143nMAssay Description:Partial agonist activity at RXRalpha (unknown origin) expressed in COS1 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50391814(CHEMBL2146901)
Affinity DataEC50:  143nMAssay Description:Partial agonist activity at RXRalpha expressed in human Cos1 cells after 18 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50391814(CHEMBL2146901)
Affinity DataEC50:  143nMAssay Description:Agonist activity at human RXRalpha expressed in African green monkey COS1 cells harboring CRBP2-tk-luc reporter incubated for 18 hrs by steady-glo lu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50391814(CHEMBL2146901)
Affinity DataKd:  1.59E+3nMAssay Description:Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant using SRC1 as...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50391814(CHEMBL2146901)
Affinity DataKd:  280nMAssay Description:Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant using PGC-1al...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50391814(CHEMBL2146901)
Affinity DataKd:  330nMAssay Description:Binding affinity to human PPARgamma-LBD (206 to 477 residues)/human RXRalpha-LBD (224 to 462 residues) heterodimer assessed as dissociation constant ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50391814(CHEMBL2146901)
Affinity DataIC50: 431nMAssay Description:Displacement of CU-6PMN from human PPARgamma-LBD (206 to 477 residues)/human RXRalpha-LBD (224 to 462 residues) heterodimer incubated for 30 mins by ...More data for this Ligand-Target Pair
In DepthDetails
PubMed