BDBM50389035 CHEMBL2064419

SMILES O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1

InChI Key InChIKey=FPFCFOIMTFHSNY-UHFFFAOYSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50389035   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Sanofi Research & Development

Curated by ChEMBL

LigandBDBM50389035(CHEMBL2064419)Copy SMILESCopy InChI

Affinity DataIC50: 118nMAssay Description:Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Sanofi Research & Development

Curated by ChEMBL

LigandBDBM50389035(CHEMBL2064419)Copy SMILESCopy InChI

Affinity DataIC50: 42nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Sanofi Research & Development

Curated by ChEMBL

LigandBDBM50389035(CHEMBL2064419)Copy SMILESCopy InChI

Affinity DataIC50: 2.13E+3nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kalpha expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
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TargetSerine/threonine-protein kinase mTOR(Human)
Sanofi Research & Development

Curated by ChEMBL

LigandBDBM50389035(CHEMBL2064419)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Sanofi Research & Development

Curated by ChEMBL

LigandBDBM50389035(CHEMBL2064419)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kgamma expressed in baculovirus infected insect sf9 cells using PI(4,5)P2 as substrate preincubated...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Sanofi Research & Development

Curated by ChEMBL

LigandBDBM50389035(CHEMBL2064419)Copy SMILESCopy InChI

Affinity DataIC50: 42nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Sanofi Research & Development

Curated by ChEMBL

LigandBDBM50389035(CHEMBL2064419)Copy SMILESCopy InChI

Affinity DataIC50: 118nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Sanofi Research & Development

Curated by ChEMBL

LigandBDBM50389035(CHEMBL2064419)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
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TargetCytochrome P450 3A4(Human)
Sanofi

Curated by ChEMBL

LigandBDBM50389035(CHEMBL2064419)Copy SMILESCopy InChI

Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
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TargetSerine/threonine-protein kinase mTOR(Human)
Sanofi Research & Development

Curated by ChEMBL

LigandBDBM50389035(CHEMBL2064419)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Sanofi Research & Development

Curated by ChEMBL

LigandBDBM50389035(CHEMBL2064419)Copy SMILESCopy InChI

Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL