BindingDB BDBM50383191 CHEMBL2031893

BDBM50383191 CHEMBL2031893

SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)c2cc1OC

InChI Key InChIKey=SBLMCLDRWJNEJK-UHFFFAOYSA-N

Data 4 KI 36 IC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 40 hits for monomerid = 50383191

Insulin receptor(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 10nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Hepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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PubMed PDB

3D Structure (crystal)

Serine/threonine-protein kinase pim-2(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 2.50E+4nMAssay Description:Inhibition of PIM2More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

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PubMed

Serine/threonine-protein kinase pim-1(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 2.50E+4nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Tyrosine-protein kinase JAK2(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1.00E+3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Tyrosine-protein kinase JAK1(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1.00E+4nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Fibroblast growth factor receptor 1(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1.00E+3nMAssay Description:Inhibition of FGFRKMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

RAC-alpha serine/threonine-protein kinase(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1.00E+4nMAssay Description:Inhibition of PKBalphaMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Mast/stem cell growth factor receptor Kit(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 100nMAssay Description:Inhibition of c-KITMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

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PubMed

Tyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1.00E+4nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

RAC-beta serine/threonine-protein kinase(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 2.50E+4nMAssay Description:Inhibition of PKBbetaMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Tyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 10nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Tyrosine-protein kinase ABL1(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 10nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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PubMed

Angiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 100nMAssay Description:Inhibition of TIE2More data for this Ligand-Target Pair

PDB KEGG
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PubMed

Proto-oncogene tyrosine-protein kinase Src(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 10nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

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PubMed

Tyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 10nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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PubMed

Aurora kinase A(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1.00E+3nMAssay Description:Inhibition of aurora-1More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Vascular endothelial growth factor receptor 2(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 10nMAssay Description:Inhibition of VEGFR2 by HTRF assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed PDB

3D Structure (crystal)

Hepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 20nMAssay Description:Inhibition of HGF-mediated c-met autophosphorylation in serum-starved human PC3 cells after 1 hr by electrochemiluminescent immunoassayMore data for this Ligand-Target Pair

PDB KEGG
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PubMed PDB

3D Structure (crystal)

Hepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 7.80nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
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PubMed PDB

3D Structure (crystal)

Cyclin-dependent kinase 5 activator 1(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1.00E+5nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Hepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 10nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed PDB

3D Structure (crystal)

Aurora kinase B(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1.00E+4nMAssay Description:Inhibition of aurora-2More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Vascular endothelial growth factor receptor 2(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 10nMAssay Description:Inhibition of VEGFR2 by HTRF assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed PDB

3D Structure (crystal)

Insulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 10nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Hepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 20nMAssay Description:Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassayMore data for this Ligand-Target Pair

PDB KEGG
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CHEMBL PC cid PC sid PDB Similars

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PubMed PDB

3D Structure (crystal)

Proto-oncogene tyrosine-protein kinase receptor Ret(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 10nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair

PDB KEGG
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CHEMBL PC cid PC sid PDB Similars

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PubMed

Hepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed PDB

3D Structure (crystal)

Ribosomal protein S6 kinase beta-1(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1.00E+3nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Hepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 10nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed PDB

3D Structure (crystal)

cAMP-dependent protein kinase catalytic subunit alpha(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1.00E+5nMAssay Description:Inhibition of PKAalphaMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

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PubMed

Mitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1.00E+3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

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PubMed

Ribosomal protein S6 kinase alpha-5(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1.00E+4nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Mitogen-activated protein kinase 9(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 1.00E+5nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Mitogen-activated protein kinase 3(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

IC50: 2.50E+4nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Macrophage-stimulating protein receptor(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

Ki: 1nMAssay Description:Inhibition of RON by HTRF assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Macrophage-stimulating protein receptor(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

Ki: 1nMAssay Description:Inhibition of RON by HTRF assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article
PubMed

Hepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

Ki: 1nMAssay Description:Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assayMore data for this Ligand-Target Pair

PDB KEGG
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3D Structure (crystal)

Insulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL

BDBM50383191(CHEMBL2031893)

Ki: 32nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair

PDB KEGG
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PubMed

Filter my 40 hits

Targets 29▿
- Hepatocyte growth factor receptor 8
- Vascular endothelial growth factor receptor 2 3
- Macrophage-stimulating protein receptor 2
- Insulin-like growth factor 1 receptor 2
- Tyrosine-protein kinase Lck 1
- Mitogen-activated protein kinase 3 1
- Tyrosine-protein kinase BTK 1
- Mitogen-activated protein kinase 9 1
- Serine/threonine-protein kinase pim-1 1
- Tyrosine-protein kinase JAK1 1
- Serine/threonine-protein kinase pim-2 1
- Angiopoietin-1 receptor 1
- Mast/stem cell growth factor receptor Kit 1
- Ribosomal protein S6 kinase beta-1 1
- Mitogen-activated protein kinase 14 1
- Aurora kinase B 1
- Insulin receptor 1
- Fibroblast growth factor receptor 1 1
- Aurora kinase A 1
- Cyclin-dependent kinase 5 activator 1 1
- Tyrosine-protein kinase ABL1 1
- RAC-beta serine/threonine-protein kinase 1
- cAMP-dependent protein kinase catalytic subunit alpha 1
- Ribosomal protein S6 kinase alpha-5 1
- RAC-alpha serine/threonine-protein kinase 1
- Tyrosine-protein kinase JAK3 1
- Tyrosine-protein kinase JAK2 1
- Proto-oncogene tyrosine-protein kinase receptor Ret 1
- Proto-oncogene tyrosine-protein kinase Src 1
Publications 5▿
- J Med Chem 55: 1868-97 (2012) 34
- J Med Chem 55: 1858-67 (2012) 2
- Eur J Med Chem 83: 581-93 (2014) 2
- Eur J Med Chem 64: 62-73 (2013) 1
- Bioorg Med Chem 21: 2843-55 (2013) 1
Institutions 3▿
- Amgen 36
- Shenyang Pharmaceutical University 2
- Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) 2
Affinity: 1 to 1.0E+5 nM▿
- Ki 4
- IC50 36
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 0