BDBM50382959 CEP-32496::CHEMBL2029988::US9730937, Example 261
SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)c2cc1OC
InChI Key InChIKey=DKNUPRMJNUQNHR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 62 hits for monomerid = 50382959
TargetVascular endothelial growth factor receptor 1(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataKd: 14nMAssay Description:Binding affinity to FLT-1 (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
Affinity DataKd: 8nMAssay Description:Inhibition of VEGFR2 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Affinity DataKd: 375nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Gothenburg
Curated by ChEMBL
University of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human RET kinase using IGF1Rtide as substrate incubated for 40 mins and measured by ADP-Glo assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Gothenburg
Curated by ChEMBL
University of Gothenburg
Curated by ChEMBL
Affinity DataKd: 1.5nMAssay Description:Binding affinity to RET (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
Affinity DataKd: 36nMAssay Description:Binding affinity to BRAF (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Binding affinity to BRAF V600E (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
Affinity DataKd: 39nMAssay Description:Binding affinity to CRAF (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataKd: 2.80nMAssay Description:Binding affinity to ABL (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
Affinity DataKd: 7.90nMAssay Description:Binding affinity to VEGFR2 (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Gothenburg
Curated by ChEMBL
University of Gothenburg
Curated by ChEMBL
Affinity DataKd: 2nMAssay Description:Inhibition of Ret in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataKd: 2.40nMAssay Description:Binding affinity to C-KIT (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Gothenburg
Curated by ChEMBL
University of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of RET (unknown origin) by kinomescan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 146nMAssay Description:Inhibition of CRAF (unknown origin) by kinomescan assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of ABL (unknown origin) by kinomescan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of VEGFR2 (unknown origin) by kinomescan assayMore data for this Ligand-Target Pair
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 0.330nMAssay Description:Inhibition of CCDC6-RET (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret /Nuclear receptor coactivator 4 fusion protein(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 0.410nMAssay Description:Inhibition of NCOA4-RET (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Gothenburg
Curated by ChEMBL
University of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of RET M918T (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Gothenburg
Curated by ChEMBL
University of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 319nMAssay Description:Inhibition of RET V804L (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Gothenburg
Curated by ChEMBL
University of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of wildtype RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Gothenburg
Curated by ChEMBL
University of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 168nMAssay Description:Inhibition of recombinant RET V804L (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Gothenburg
Curated by ChEMBL
University of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant RET M918T (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant CCDC6-RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
Affinity DataKd: 36nMAssay Description:Inhibition of wild type BRAF in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of Aurora B in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of ERK2 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of ERK1 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Inhibition of EPHA2 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 22nMAssay Description:Inhibition of EGFR in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 9nMAssay Description:Inhibition of CSF1R in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of Aurora A in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of ALK in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataKd: 3nMAssay Description:Inhibition of Abl1 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 39nMAssay Description:Inhibition of CRAF in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 99nMAssay Description:Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...More data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of IGFR1 in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of INSR in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair