BDBM50380313 CHEMBL1234354::US8633204, 286
SMILES COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n([C@H]2CC[C@@H](CC2)OCCO)c1=O
InChI Key InChIKey=XDLYKKIQACFMJG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 50380313
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Affinity DataIC50: 8.30nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2/PS as substrate preincubated for 15 mins before substrate addition by luciferase-based luminescen...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Human)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human mTOR incubated for 30 mins by ATP competition based fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human PI3Kgamma incubated for 30 mins by ATP competition based fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human PI3Kdelta incubated for 30 mins by ATP competition based fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human PI3Kbeta incubated for 30 mins by ATP competition based fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human PI3Kalpha incubated for 30 mins by ATP competition based fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Mouse)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of mouse PI3Kgamma expressed in insect cells assessed as fluorescence polarization incubated for 30 mins by ATP competitive assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Mouse)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of mouse PI3Kdelta expressed in insect cells assessed as fluorescence polarization incubated for 30 mins by ATP competitive assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Mouse)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of mouse PI3Kbeta expressed in insect cells assessed as fluorescence polarization incubated for 30 mins by ATP competitive assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Mouse)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of mouse PI3Kalpha expressed in insect cells assessed as fluorescence polarization incubated for 30 mins by ATP competitive assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate by Kinase-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of AKT phosphorylation at Ser 473 in human BT20 cellsMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Affinity DataIC50: 8.30nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2/PS as substrate compound preincubated for 15 mins by luciferase-based luminescence assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Human)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataIC50: 7.90nMAssay Description:Inhibition of mTOR (unknown origin) after 40 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Human)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataIC50: 7.90nMAssay Description:Inhibition of mTOR (unknown origin) assessed as inhibition of 4EBP-1 phosphorylation preincubated for 15 mins before substrate addition by TR-FRET as...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Affinity DataIC50: 4.85nMpH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Affinity DataKi: 0.570nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Mouse)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataKi: 0.570nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of PI3Kdelta (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Pkucare Pharmaceutical R & D Center
Curated by ChEMBL
Affinity DataKi: 1.80nMAssay Description:Inhibition of PI3Kalpha (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Inhibition of PI3Kgamma (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataKi: 2.10nMAssay Description:Inhibition of PI3Kbeta (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence as...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Human)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
TargetSerine/threonine-protein kinase mTOR(Human)
South China University of Technology
Curated by ChEMBL
South China University of Technology
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair