BDBM50379157 CHEMBL1234899::US8703811, 57

SMILES Cc1nc2cc(OC(F)(F)F)ccc2n1-c1ccc(s1)C(=O)NC1CC1

InChI Key InChIKey=ACFOZQUWTKSSQQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50379157   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. falciparum)
Genzyme

US Patent
LigandPNGBDBM50379157(CHEMBL1234899 | US8703811, 57)
Affinity DataIC50: 64nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 2D6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50379157(CHEMBL1234899 | US8703811, 57)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP2D6 using bufuralol as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50379157(CHEMBL1234899 | US8703811, 57)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH (30 to 396 residues) expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate after 20...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed