BDBM50374401 CHEMBL407217

SMILES c1cc(c(cc1C(F)(F)F)NC(=O)Nc2cc(ccc2O)Cl)Cl

InChI Key InChIKey=OUDXRNQPVSMGDW-UHFFFAOYSA-N

Data  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50374401   

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Qingdao University Medical College

Curated by ChEMBL
LigandPNGBDBM50374401(CHEMBL407217)
Affinity DataEC50:  3.40E+3nMAssay Description:Type-1 positive allosteric modulation of human alpha7 nAChR expressed in xenopus laevis oocytes assessed as increase in acetylcholine induced channel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Qingdao University Medical College

Curated by ChEMBL
LigandPNGBDBM50374401(CHEMBL407217)
Affinity DataEC50:  3.40E+3nMAssay Description:Activity at alpha7 nACh receptor assessed as modulation of acetylcholine-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Qingdao University Medical College

Curated by ChEMBL
LigandPNGBDBM50374401(CHEMBL407217)
Affinity DataEC50:  3.40E+3nMAssay Description:Positive allosteric modulation of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in Ach-induced current at -90 mV membra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)