BDBM50361471 CHEMBL1614745

SMILES O[C@H](CCC(O)=O)C(O)=O

InChI Key InChIKey=HWXBTNAVRSUOJR-UHFFFAOYSA-N

Data  6 KI  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50361471   

TargetMethylcytosine dioxygenase TET2(Mus musculus)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 4.00E+6nMAssay Description:Inhibition of recombinant mouse TET2More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 3.60E+6nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEgl nine homolog 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 7.30E+6nMAssay Description:Inhibition of N-terminal His-tagged human PHD2 catalytic domain (181 to 426 residues) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 1.50E+6nMAssay Description:Inhibition of N-terminal His-tagged human FIH expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 3.20E+5nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 2.03E+5nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDNA oxidative demethylase ALKBH2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 2.12E+5nMAssay Description:Inhibition of ABH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDNA oxidative demethylase ALKBH2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 4.24E+5nMAssay Description:Inhibition of ABH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 1.06E+5nMAssay Description:Inhibition of KDM2A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of KDM4AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylcytosine dioxygenase TET1(Mus musculus)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 4.00E+6nMAssay Description:Inhibition of recombinant mouse TET1More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of His10-FLAG tagged human TET2 catalytic domain (Q969 to I2002 residues) expressed in Sf9 cells using 5-methylcytosine as substrate prein...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDNA oxidative demethylase ALKBH2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 4.24E+5nMAssay Description:Inhibition of N-terminal His-tagged human full length ALKBH2 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase alkB homolog 3(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 8.30E+6nMAssay Description:Inhibition of human ALKBH3 using ss-m1A DNA as substrate by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 1.89E+5nMAssay Description:Inhibition of FIH (unknown origin) assessed as hydroxylation of HIF1alphaCAD by MALDI-TOF-MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProlyl 4-hydroxylase(PBCV-1)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of KDM4CMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 1.06E+5nMAssay Description:Inhibition of KDM2AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of KDM4A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataKi:  2.30E+4nMAssay Description:Competitive inhibition of His10-FLAG tagged human TET2 catalytic domain (Q969 to I2002 residues) expressed in Sf9 cells using 5-methylcytosine as sub...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataKi:  7.40E+4nMAssay Description:Inhibition of KDM2A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataKi:  2.46E+5nMAssay Description:Competitive inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosin...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEgl nine homolog 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataKi:  6.25E+5nMAssay Description:Inhibition of PHD2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataKi:  1.00E+7nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed