BDBM50359807 CHEMBL1928705

SMILES C[C@H](CN(C)C)Oc1nc(Nc2cc3cccc(Cl)c3cn2)cnc1C#N

InChI Key InChIKey=SRBJWIBAMIKCMV-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50359807   

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50359807(CHEMBL1928705)
Affinity DataIC50: 13nMAssay Description:Competitive inhibition of human CHK1 using ATP as substrate by DELFIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50359807(CHEMBL1928705)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50359807(CHEMBL1928705)
Affinity DataIC50: 55nMAssay Description:Inhibition of CHK1 in human HT-29 cells assessed as etoposide-induced G2 check point arrest after 21 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50359807(CHEMBL1928705)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50359807(CHEMBL1928705)
Affinity DataIC50: 1.00E+5nMAssay Description:Competitive inhibition of human CHK2 using ATP as substrate by DELFIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50359807(CHEMBL1928705)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human ERG overexpressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed