BDBM50358430 CHEMBL1614725

SMILES CC(C)(O)CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12

InChI Key InChIKey=ZYQXEVJIFYIBHZ-UHFFFAOYSA-N

Data  39 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 50358430   

TargetMitogen-activated protein kinase 14(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged p38alpha expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scinti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of N-terminus flag-tagged CSK expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFocal adhesion kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged FAK expressed in baculovirus infected insect cells using ATP as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged LynA expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged ASK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 2 group C member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged TAK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminus flag-tagged MEKK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintilla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminus flag-tagged IKK-beta expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scinti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged JNK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged ERK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of N-terminus flag-tagged Lck expressed in baculovirus infected insect cells using ATP as substrate after 20 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged PKCtheta expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scinti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged GSK3-beta expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scint...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged B-raf expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintilla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged TTK expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged PLK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 4nMAssay Description:Inhibition of human wild type EGFR expressed in Sf9 cells using [gamma32P]-ATP after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 23nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged EGFR cytoplasmic domain (669 to 1210) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 17nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged HER2 cytoplasmic domain (676 to 1255) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of C-terminal His6-tagged HER2 (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells using TK as substrate preincubated fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged VEGRF2 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of N-terminus 6XHis-tagged Aurora-B expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scint...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1nMAssay Description:Inhibition of EGFR (unknown origin) after 120 mins by HotSpot assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 3nMAssay Description:Inhibition of HER2 (unknown origin) after 120 mins by HotSpot assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminus peptide (DYKDDDD)-tagged HER4 expressed in baculovirus infected insect cells using [gamma-32P]ATP as substrate after 60 mins...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of C-terminus flag-tagged MEK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of N-terminus flag-tagged MEK5 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 17nMAssay Description:Inhibition of human N-terminus peptide (DYKDDDD)-tagged HER2 expressed in baculovirus infected insect cells using [gamma-32P]ATP as substrate after 6...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of N-terminus flag-tagged c-MET expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged VEGRF1 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of N-terminus flag-tagged LynB expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged FGFR1 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged FGFR3 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged PDGFRalpha expressed in baculovirus infected insect cells using ATP as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged PDGFRbeta expressed in baculovirus infected insect cells using ATP as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged TIE2 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged c-kit expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged IGF-1R expressed in baculovirus infected insect cells using ATP as substrate after 20 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged Src expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed