BDBM50336843 3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonitrile::CHEMBL1672288

SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N

InChI Key InChIKey=LVXAMCKZCLWWTF-UHFFFAOYSA-N

Data  47 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 47 hits for monomerid = 50336843   

TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to muscarinic M4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to dopamine D4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1B) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to dopamine D5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to DATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to KORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H4 receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to muscarinic M5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR6 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR8 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to MORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to NETMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to SERT receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic alpha2B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic beta2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT1B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT1E receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT5A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT7 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic alpha1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic Alpha-1B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic Alpha-1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic alpha2A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic Alpha-2C receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic beta1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic beta3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1A) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to DORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed