BDBM50330259 CHEMBL1236391::N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide::N-[3-(methylsulfanyl)-1-phenyl-1H-indazol-6-yl]piperidine-4-carboxamide::US8822447, 6::US9771375, Example 6

SMILES CSc1nn(-c2ccccc2)c2cc(NC(=O)C3CCNCC3)ccc12

InChI Key InChIKey=DHDKYDLNUPJXFQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50330259   

TargetKetohexokinase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50330259(N-[3-(methylsulfanyl)-1-phenyl-1H-indazol-6-yl]pip...)
Affinity DataIC50: 590nMT: 2°CAssay Description:An enzymatic assay was developed to measure KHK-mediated conversion of D-fructose to Fructose-1-P (F-1-P) using High Throughput Mass Spectroscopy (HT...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 1A2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50330259(N-[3-(methylsulfanyl)-1-phenyl-1H-indazol-6-yl]pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50330259(N-[3-(methylsulfanyl)-1-phenyl-1H-indazol-6-yl]pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50330259(N-[3-(methylsulfanyl)-1-phenyl-1H-indazol-6-yl]pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50330259(N-[3-(methylsulfanyl)-1-phenyl-1H-indazol-6-yl]pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP2C19More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50330259(N-[3-(methylsulfanyl)-1-phenyl-1H-indazol-6-yl]pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50330259(N-[3-(methylsulfanyl)-1-phenyl-1H-indazol-6-yl]pip...)
Affinity DataIC50: 8.13E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKetohexokinase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50330259(N-[3-(methylsulfanyl)-1-phenyl-1H-indazol-6-yl]pip...)
Affinity DataIC50: 330nMAssay Description:Inhibition of KHK-mediated conversion of D-fructose to fructose-1-phosphate after 60 mins by high throughput mass spectrometry analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKetohexokinase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50330259(N-[3-(methylsulfanyl)-1-phenyl-1H-indazol-6-yl]pip...)
Affinity DataIC50: 590nMAssay Description:An enzymatic assay was developed to measure KHK-mediated conversion of D-fructose to Fructose-1-P (F-1-P) using High Throughput Mass Spectroscopy (HT...More data for this Ligand-Target Pair
In DepthDetails
US Patent