BDBM50329576 (R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-fluoro-3-(5-fluoropent-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1270835

SMILES CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)F)cc1)c1ccc(F)c(c1)C#CCCCF

InChI Key InChIKey=ZSIZOKHLIKKQIV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50329576   

TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329576((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329576((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50: 400nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329576((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329576((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50: 900nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRenin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329576((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of renin by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed