BDBM50317547 CHEMBL4163812

SMILES OC(=O)CNC(=O)c1c(O)n(C2CCCCC2)c(=O)n(C2CCCCC2)c1=O

InChI Key InChIKey=NVTKJBXOBFRPLQ-UHFFFAOYSA-N

Data  1 KI  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50317547   

TargetProlyl hydroxylase EGLN2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50317547(CHEMBL4163812)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of PHD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProlyl hydroxylase EGLN3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50317547(CHEMBL4163812)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of PHD3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEgl nine homolog 1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50317547(CHEMBL4163812)
Affinity DataIC50: 22nMAssay Description:Inhibition of PHD2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEgl nine homolog 1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50317547(CHEMBL4163812)
Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant human PHD2 using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProlyl 3-hydroxylase OGFOD1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50317547(CHEMBL4163812)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant human OGFOD1 using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProlyl 4-hydroxylase(PBCV-1)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50317547(CHEMBL4163812)
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50317547(CHEMBL4163812)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of recombinant human FIH using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asco...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProlyl 4-hydroxylase(PBCV-1)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50317547(CHEMBL4163812)
Affinity DataKi:  7.65E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed