BDBM50315888 CHEMBL1090360::N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-phenylacetamide

SMILES O=C(Cc1ccccc1)Nc1cccc(c1)-c1nc2sccn2c1-c1ccnc(Nc2cccc(c2)N2CCOCC2)n1

InChI Key InChIKey=XKZQZMSAWVDRSP-UHFFFAOYSA-N

Data  57 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 57 hits for monomerid = 50315888   

TargetProtein kinase C gamma type(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKCgammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 29nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 71nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 26nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 650nMAssay Description:Inhibition of MST2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 310nMAssay Description:Inhibition of NeK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 13(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of p38deltaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of p38-gammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 531nMAssay Description:Inhibition of PAK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PIM2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKCdeltaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 73nMAssay Description:Inhibition of ErbB2 by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant IGF1R expressed in Sf21 cells by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 610nMAssay Description:Inhibition of EGFR intracellular phosphorylation in human A431 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SGKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 310nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Tyk2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of TrkAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of TrkBMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDeath-associated protein kinase 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ZipKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 310nMAssay Description:Inhibition of NEK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDC42BPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 680nMAssay Description:Inhibition of ErbB2 intracellular phosphorylation in human N87 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 660nMAssay Description:Inhibition of Aurora 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDC2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant IGF1R expressed in Sf21 cells by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 80nMAssay Description:Inhibition of InsRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C eta type(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKCetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase D2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKD2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase A(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 65nMAssay Description:Inhibition of Aurora1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 320nMAssay Description:Inhibition of BlkMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 65nMAssay Description:Inhibition of Flt4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase I isoform delta(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 740nMAssay Description:Inhibition of CK1deltaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of cKitMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of DyrK1AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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