BDBM50315213 2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-1H-benzimidazole::4,4'-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine::CHEMBL586702::TCMDC-137004
SMILES FC(F)c1nc2ccccc2n1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1
InChI Key InChIKey=HGVNLRPZOWWDKD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 79 hits for monomerid = 50315213
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 50nMAssay Description:Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Competitive inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 50nMAssay Description:Inhibition of wild type PI3Kalpha (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 50nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 44nMAssay Description:Inhibition of PI3Kbeta (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 51nMAssay Description:Inhibition of PI3Kgamma (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of Palermo
Curated by ChEMBL
University of Palermo
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of PI3K p110gamma/p85alpha (unknown origin) assessed as reduction in PIP2 to PIP3 conversion by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Inhibition of PI3K-delta (unknown origin) after 40 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 44nMAssay Description:Inhibition of PI3K-beta (unknown origin) after 40 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Competitive inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 50nMAssay Description:Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 51nMAssay Description:Inhibition of PI3K-gamma (unknown origin) after 40 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate after 1 hr by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human full length His-tagged PI3K p110gamma expressed in baculovirus expression system by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of Michigan
Curated by ChEMBL
University of Michigan
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant human full length His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system coexpressing PIK3R1 by TR-F...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human full length His-tagged PI3K p110alpha/p85alpha expressed in baculovirus expression system coexpressing PIK3R1 by TR-F...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of PI3Kbeta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of PI3Kdelta (unknown origin) expressed in SF21 cells using phosphatidylinositol as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of P13Kdelta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal 6xHis-tagged recombinant full-length human PI3Kdelta expressed in baculovirus infected Sf21 insect cells by ADP-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human PI3Kgamma expressed in baculovirus infected Sf21 insect cells by ADP-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of N-terminal 6xHis-tagged recombinant, full length human PI3Kbeta by ADP-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of N-terminal GST-fused full-length human PI3Kalpha (1 to 1068 residues) expressed in baculovirus expression system using PIP2 as substrat...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of PI3Kalpha (unknown origin) expressed in SF21 cells using phosphatidylinositol as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of P13Kgamma (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of P13Kbeta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of P13Kalpha (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human PI3Kdelta by TR-FRET based Adapta assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human PI3Kgamma by TR-FRET based Adapta assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human PI3Kbeta by TR-FRET based Adapta assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human PI3Kalpha by TR-FRET based Adapta assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Competitive inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Competitive inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 83nMAssay Description:Inhibition of human His-tagged PI3K p110gamma after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of human His-tagged PI3K p110delta after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibition of human recombinant PI3K p110beta expressed in Sf21 insect cells using phosphatidylinositol as substrate after 1 hr by phosphoimagingMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of p110deltaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of p110gammaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of p110betaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of p110alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6K-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of PI3K p110delta (unknown origin)More data for this Ligand-Target Pair