BDBM50314780 CHEMBL1091199::N-Cyclopropyl-3-(1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-4-methylbenzamide::N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-4-methylbenzamide

SMILES Cc1ccc(cc1-c1cc2cnn(-c3ccc(F)cc3F)c2n(C)c1=O)C(=O)NC1CC1

InChI Key InChIKey=XQRUWZMHPKNIDA-UHFFFAOYSA-N

Data  2 KI  1 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50314780   

TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  0.310nMAssay Description:Binding affinity to p38alpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to Kdr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to Lck by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to c-Kit by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of LPS-induced MK2 phosphorylation in human whole blood treated 30 mins before LPS challenge measured after 45 mins by FACS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to P38alpha MAPK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed