BDBM50310190 2-p-Tolyl-chromen-4-one::2-p-tolyl-4H-chromen-4-one::CHEMBL16861

SMILES Cc1ccc(cc1)-c1cc(=O)c2ccccc2o1

InChI Key InChIKey=OPHKKQQCOYMLPW-UHFFFAOYSA-N

Data  2 KI  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50310190   

TargetAmine oxidase [flavin-containing] B(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50310190(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
Affinity DataIC50: 2.38E+3nMAssay Description:Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells by para-tyramine oxidation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50310190(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
Affinity DataIC50: 2.78E+4nMAssay Description:Inhibition of human full length ARTD2 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50310190(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human full length ARTD1 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50310190(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
Affinity DataIC50: 2.75E+4nMAssay Description:Inhibition of human full length ARTD2 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50310190(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
Affinity DataIC50: 7.08E+3nMAssay Description:Inhibition of human full length ARTD1 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50310190(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human recombinant ARTD1 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50310190(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50310190(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
Affinity DataIC50: 52nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] B(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50310190(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
Affinity DataKi:  990nMAssay Description:The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Birla Institute of Technology

LigandPNGBDBM50310190(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
Affinity DataKi:  3.32E+3nMAssay Description:The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed