BDBM50302107 CHEMBL567893::Grassystatin A

SMILES COC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](OC(=O)[C@@H](OC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)[C@@H](C)O

InChI Key InChIKey=JZYWSTGTBRHGTL-UHFFFAOYSA-N

Data  75 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 75 hits for monomerid = 50302107   

Target72 kDa type IV collagenase(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MMP2 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MMP12 catalytic domain after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStromelysin-3(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MMP11 catalytic domain after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStromelysin-2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MMP10 catalytic domain after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ACE1 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin K-dependent protein C(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of activated protein C after 10 to 15 mins by fluorescence assay in presence of 50% glycineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MMP9 catalytic domain after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeutrophil collagenase(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MMP8 catalytic domain after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrilysin(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MMP7 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStromelysin-1(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MMP3 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MMP13 catalytic domain after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM10 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MMP1 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKallikrein-8(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of kallikrein 8 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKallikrein-5 [D153N](Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of kallikrein 5 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKallikrein-4(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of kallikrein 4 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor XI(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of factor 11a after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of factor 10a after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetChymotrypsin-like elastase family member 1(Pig)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of porcine pancreatic elastase after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of urokinase after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 26nMAssay Description:Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated for 15 mins followed b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin E(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged cathepsin E (Gln18 to Pro396 residues) using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 40nMAssay Description:Inhibition of cathepsin D using MCA-KPILFFRLK(Dnp)-D-R-NH2 as substrate incubated for 10 to 15 mins prior to substrate addition measured every 5 min ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin E(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of cathepsin E using MCA-KPILFFRLK(Dnp)-D-R-NH2 as substrate incubated for 10 to 15 mins prior to substrate addition measured every 5 min ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 40nMAssay Description:Inhibition of cathepsin D by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin E(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of cathepsin E by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin E(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of cathepsin E in human MCF7 cells treated for 1 hr measured after washout and trypsin treatment by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of cathepsin D in human MCF7 cells treated for 1 hr measured after washout and trypsin treatment by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of TACE after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 9(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DPP9 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase gamma(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human lung tryptase gamma1 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of bovine pancreatic trypsin after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProthrombin(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of thrombin alpha after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRenin(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human renin after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlasminogen(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human plasmin after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlasma kallikrein(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of plasma kallikrein after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPapain(Papaya)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of papaya papain after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MMP14 catalytic domain after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin K(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cathepsin X after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-4(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of caspase 4 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-3(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of caspase 3 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of caspase 2 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-1(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of caspase 1 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of calpain 1 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 9(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM9 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of tryptase beta2 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TACE after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin E(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of cathepsin E in human MCF7 cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-5(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of caspase 5 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin E(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 0.886nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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