BDBM50300196 10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6.1.0^{2,7}.0^{14,18}]octadeca-1(18),2(7),3,5,11,14,16-heptaen-9-one::CHEMBL584052::atropisomer 1::atropisomer 2

SMILES Oc1ccc(cc1)C1c2c[nH]c3nccc(-c4ccccc4NC1=O)c23

InChI Key InChIKey=LGIBDQRYOFBMTC-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50300196   

TargetTyrosine-protein kinase JAK3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of JAK3 in human HT2 cells assessed as inhibition of IL2-induced STAT5 phosphorylation by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataIC50: 270nMAssay Description:Inhibition of JAK2 in human TF1 cells assessed as inhibition of GMCSF-induced STAT5 phosphorylation by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataKi:  0.00100nMAssay Description:Inhibition of recombinant JAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of recombinant JAK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of recombinant JAK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataKi:  17nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataKi:  190nMAssay Description:Inhibition of cKitMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataKi:  340nMAssay Description:Inhibition of GCKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed