BDBM50296949 (2Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid::(Z)-5-(4-Chlorophenyl)-3-phenylpent-2-enoicAcid::(Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid::CHEMBL539134::PS48

SMILES OC(=O)\C=C(\CCc1ccc(Cl)cc1)c1ccccc1

InChI Key InChIKey=LLJYFDRQFPQGNY-UHFFFAOYSA-N

Data  1 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50296949   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Universit£Tsklinikum Frankfurt

LigandPNGBDBM50296949(PS48 | (2Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoi...)
Affinity DataIC50: 9.70E+4nMpH: 7.4 T: 2°CAssay Description:The AlphaScreen Assay (Perkin Elmer) was performed according to the manufacturer's protocol in 384-well microtiter plates. Incubations were performe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target3-phosphoinositide-dependent protein kinase 1(Human)
Universit£Tsklinikum Frankfurt

LigandPNGBDBM50296949(PS48 | (2Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoi...)
Affinity DataKd:  1.03E+4nMAssay Description:Binding affinity to PDK1 (50 to 359) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target3-phosphoinositide-dependent protein kinase 1(Human)
Universit£Tsklinikum Frankfurt

LigandPNGBDBM50296949(PS48 | (2Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoi...)
Affinity DataKd:  1.03E+4nMAssay Description:Binding affinity to human PDPK1 Y288G/Q292A mutant expressed in insect cell system assessed as substrate phosphorylation by isothermal titration calo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)