BDBM50285416 CHEMBL4161733
SMILES [H][C@]1(CC[C@@H](CC1)c1ccnc2ccc(F)cc12)[C@@H](C)C(=O)Nc1ccc(Cl)cc1
InChI Key InChIKey=KRTIYQIPSAGSBP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 50285416
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of TDO in HEK cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human IDO1 using L-tryptophan as substrate assessed as reduction in N-formyl kynurenine formation by UV-visible spectroscopic analysisMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human TDOMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
Affinity DataKd: 470nMAssay Description:Binding affinity to IDO1 (unknown origin) assessed as dissociation constant by bio-layer interferometry assayMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of human IDO1 expressed in Escherichia coli BL21(DE3) using D-tryptophan as substrate assessed as formation of kynurenine productionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of IDO1 in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells in presence of heme measured after 20 hrs by heme-competitive binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IDO1 in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of IDO1 in HEK293 cellsMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of IDO1 in recombinant IFN-gamma induced mouse M109 cells incubated for 18 hrs by fluorescence microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of IDO1 in recombinant IFN-gamma induced human HeLa cells incubated for 18 hrs by fluorescence microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated human HeLa cells preincubated for 2 hrs followed by IFNgamma stimulation and measured after 18 hrs byMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated mouse M109 cells preincubated for 2 hrs followed by IFNgamma stimulation and measured after 18 hrs byMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS-stimulated human whole blood preincubated for 4 hrs followed by IFNgamma/LPS stimulation and incubated for 18 hrs ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human IDO1 assessed as reduction in kynurenine productionMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of IDO1 in human SKOV3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of IDO1 in human whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 730nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of IDO1 in human SKOV3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of IDO1 in human whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of IDO1 in human HeLa cells preincubated for 1 hr followed by IFN-gamma stimulation and measured after 20 hrs by Ehrlich colorimetric reag...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells using L-tryptophan as substrate incubated for 48 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of IDO1 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of IDO1 in human SKOV3 assessed as reduction in kynurenine productionMore data for this Ligand-Target Pair