BDBM50274605 CHEMBL4128266

SMILES N#C\C=C\c1ccc(o1)-c1nc2cnc3[nH]ccc3c2n1C1CCCCC1

InChI Key InChIKey=UUVPPNMLZDVPOR-UHFFFAOYSA-N

Data  5 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50274605   

TargetTyrosine-protein kinase JAK3(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274605(CHEMBL4128266)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274605(CHEMBL4128266)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of kinase tracer-04 binding to C-terminal NanoLuc tagged full length JAK1 (unknown origin) expressed in HEK cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274605(CHEMBL4128266)
Affinity DataIC50: 44nMAssay Description:Inhibition of human TYK2 using KKSRGDYMTMQIG as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274605(CHEMBL4128266)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human JAK3 (781 to 1124 residues) expressed in baculovirus expression system assessed as reduction in polypeptide substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274605(CHEMBL4128266)
Affinity DataIC50: 12nMAssay Description:Inhibition of human JAK1 using poly[Glu:Tyr] (4:1) as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274605(CHEMBL4128266)
Affinity DataIC50: 53nMAssay Description:Inhibition of human JAK2 using poly[Glu:Tyr] (4:1) as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274605(CHEMBL4128266)
Affinity DataEC50:  740nMAssay Description:Inhibition of kinase tracer-05 binding to C-terminal NanoLuc tagged full length JAK3 (unknown origin) expressed in HEK cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274605(CHEMBL4128266)
Affinity DataEC50:  1.33E+4nMAssay Description:Inhibition of kinase tracer-05 binding to C-terminal NanoLuc tagged full length BTK (unknown origin) expressed in HEK cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274605(CHEMBL4128266)
Affinity DataEC50:  7.71E+3nMAssay Description:Inhibition of kinase tracer-05 binding to C-terminal NanoLuc tagged full length JAK2 (unknown origin) expressed in HEK cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed