BDBM50274601 CHEMBL4127590

SMILES N#CCCc1ccc(o1)-c1nc2cnc3[nH]ccc3c2n1C1CCCCC1

InChI Key InChIKey=PLKGAHIHTTYWEV-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50274601   

TargetTyrosine-protein kinase JAK3(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274601(CHEMBL4127590)
Affinity DataIC50: 129nMAssay Description:Inhibition of recombinant human JAK3 (781 to 1124 residues) expressed in baculovirus expression system assessed as reduction in polypeptide substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274601(CHEMBL4127590)
Affinity DataIC50: 16nMAssay Description:Inhibition of human JAK1 using poly[Glu:Tyr] (4:1) as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274601(CHEMBL4127590)
Affinity DataIC50: 48nMAssay Description:Inhibition of human JAK2 using poly[Glu:Tyr] (4:1) as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274601(CHEMBL4127590)
Affinity DataIC50: 10nMAssay Description:Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274601(CHEMBL4127590)
Affinity DataIC50: 25nMAssay Description:Inhibition of human TYK2 using KKSRGDYMTMQIG as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed