BDBM50266285 CHEMBL4086276

SMILES Cc1cc2c(cc1N3C(=O)c4cccc5c4c(ccc5CCCO)C3=O)N(C(=O)N2C)C

InChI Key InChIKey=OFWWWKWUCDUISA-UHFFFAOYSA-N

Data  2 IC50  4 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50266285   

TargetBromodomain-containing protein 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50266285(CHEMBL4086276)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetTranscription initiation factor TFIID subunit 1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50266285(CHEMBL4086276)
Affinity DataKd:  9.30nMAssay Description:Binding affinity to human TAF1 tandem bromodomain (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTranscription initiation factor TFIID subunit 1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50266285(CHEMBL4086276)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human TAF1 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTranscription initiation factor TFIID subunit 1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50266285(CHEMBL4086276)
Affinity DataKd:  47nMAssay Description:Binding affinity to human TAF1 BD 2 (1501 to 1635 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant by isotherma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTranscription initiation factor TFIID subunit 1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50266285(CHEMBL4086276)
Affinity DataEC50:  70nMAssay Description:Binding affinity to TAF1 in HEK293T cells assessed as increase in TAF1 level by ITDR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTranscription initiation factor TFIID subunit 1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50266285(CHEMBL4086276)
Affinity DataKd:  2.10E+3nMAssay Description:Binding affinity to human TAF1 tandem bromodomain (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTranscription initiation factor TFIID subunit 1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50266285(CHEMBL4086276)
Affinity DataKd:  4.60E+3nMAssay Description:Binding affinity to human TAF1 BD 1 (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)