BDBM50265968 CHEMBL4065992

SMILES COCCN1[C@H](C)Cc2[nH]c(cc2C1=O)-c1nc(Nc2ccnn2C)ncc1C

InChI Key InChIKey=PNXHDOWDWLRBSB-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50265968   

TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50265968(CHEMBL4065992)Copy SMILESCopy InChI

Affinity DataIC50: 0.300nMAssay Description:Inhibition of ERK2 (unknown origin) in the presence of 60 uM ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
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TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50265968(CHEMBL4065992)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50265968(CHEMBL4065992)Copy SMILESCopy InChI

Affinity DataIC50: 0.300nMAssay Description:Inhibition of ERK2 (unknown origin) in the presence of 1 mM ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50265968(CHEMBL4065992)Copy SMILESCopy InChI

Affinity DataIC50: 130nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated RSK levelsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50265968(CHEMBL4065992)Copy SMILESCopy InChI

Affinity DataIC50: 30nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated ERK2 levelsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL