BDBM50261834 2-morpholin-4-yl-5,6-dihydro-4H-benzothiazol-7-one::5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one::5,5-dimethyl-2-morpholino-5,6-dihydrobenzo[d]thiazol-7(4H)-one::CHEMBL469099

SMILES CC1(C)Cc2nc(sc2C(=O)C1)N1CCOCC1

InChI Key InChIKey=DZXMARZBAUMWLK-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50261834   

LigandPNGBDBM50261834(5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benz...)
Affinity DataIC50: 701nMAssay Description:Inhibition of PI3K deltaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50261834(5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benz...)
Affinity DataIC50: 1.66E+3nMAssay Description:Inhibition of PI3K gammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50261834(5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benz...)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of PI3K alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50261834(5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benz...)
Affinity DataIC50: 693nMAssay Description:Inhibition of PI3K betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50261834(5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benz...)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of PI3K-mediated AKT Ser473 phosphorylation in PTEN negative human PC3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50261834(5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benz...)
Affinity DataIC50: 975nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50261834(5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benz...)
Affinity DataIC50: 693nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50261834(5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benz...)
Affinity DataIC50: 701nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50261834(5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benz...)
Affinity DataIC50: 3.45E+3nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)