BDBM50257350 CHEMBL1738877

SMILES Cn1c(CNc2cccc(c2)C(=O)NCc2ccccc2C(F)(F)F)nnc1-c1ccncc1

InChI Key InChIKey=WFOVEDJTASPCIR-UHFFFAOYSA-N

Data  19 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50257350   

TargetG protein-coupled receptor kinase 5(Bovine)
University of Michigan

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of bovine GRK5 after 5 mins after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

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TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 30nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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TargetBeta-adrenergic receptor kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 5.40nMAssay Description:Inhibition of GRK3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of PKC (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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TargetRhodopsin kinase GRK7(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of GRK7 (unknown origin)More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

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TargetG protein-coupled receptor kinase 6(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GRK6 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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TargetG protein-coupled receptor kinase 5(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

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TargetRhodopsin kinase GRK1(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of GRK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

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TargetBeta-adrenergic receptor kinase 1(Bovine)
University of Michigan

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 30nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

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TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

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TargetRhodopsin kinase GRK1(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

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TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 30nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

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TargetRhodopsin kinase GRK1(Bovine)
University of Michigan

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 5.21E+4nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) after 5 mins after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

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TargetG protein-coupled receptor kinase 5(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of recombinant human full length GST-tagged GRK5 expressed in baculovirus using ulight topo2alpha as substrate preincubated for 60 mins fo...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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TargetRho-associated protein kinase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROCK2 catalytic domain (1 to 553 residues) expressed in baculovirus expression system using STK...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

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TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 18nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

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TargetProtein kinase C alpha type(Human)
Takeda Pharmaceutical

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of human PKCalpha active using MBP as substrate after 60 mins in presence of [gamma-32]ATP by scintillation countingMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

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TargetRhodopsin kinase GRK7(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged GRK7 expressed in baculovirus using ulight topo2alpha as substrate preincubated for 60 mins fo...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

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TargetG protein-coupled receptor kinase 6(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged GRK6 expressed in baculovirus using ulight topo2alpha as substrate preincubated for 60 mins fo...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails Article
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TargetBeta-adrenergic receptor kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: 5.40nMAssay Description:Inhibition of recombinant human full length GST-tagged GRK3 expressed in baculovirus using ulight topo2alpha as substrate preincubated for 60 mins fo...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails Article
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