BDBM50250112 CHEMBL4072756

SMILES COc1cccc(c1)[C@@H](Oc1ccc2n(ncc2c1)-c1ccc(F)cc1)[C@H](C)NC(=O)C(F)(F)F

InChI Key InChIKey=FCNQMDSJHADDFT-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50250112   

TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50250112(CHEMBL4072756)
Affinity DataIC50: 0.0490nMAssay Description:Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50250112(CHEMBL4072756)
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of [3H]-aldosterone from N terminal maltose binding protein tagged human mineralocorticoid receptor LBD (726 to 984 residues) expressed ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50250112(CHEMBL4072756)
Affinity DataIC50: 0.140nMAssay Description:Transrepression of glucocorticoid receptor in Wistar rat PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins follow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50250112(CHEMBL4072756)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of fluormone labelled EL Red from human recombinant estrogen receptor alpha after 1 to 5 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEstrogen receptor beta(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50250112(CHEMBL4072756)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of fluormone labelled EL Red from human recombinant estrogen receptor beta after 1 to 5 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProgesterone receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50250112(CHEMBL4072756)
Affinity DataIC50: 1.76E+3nMAssay Description:Displacement of fluormone labelled PL Red from human recombinant progesterone receptor after 1 to 6 hrs ligand by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50250112(CHEMBL4072756)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of fluormone labelled AL green from rat recombinant His/GST-tagged androgen receptor LBD after 4 to 6 hrs by fluorescence polarization a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50250112(CHEMBL4072756)
Affinity DataIC50: 0.160nMAssay Description:Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50250112(CHEMBL4072756)
Affinity DataIC50: 0.900nMAssay Description:Displacement of fluormone labelled GS Red from human recombinant glucocorticoid receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)