BDBM50250111 CHEMBL4084664

SMILES C[C@@H](CO)NC(=O)c1cnn2c(O)cc(nc12)-c1ccccc1

InChI Key InChIKey=HXHYZXUIKFXLHE-UHFFFAOYSA-N

Data  2 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50250111   

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250111(CHEMBL4084664)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250111(CHEMBL4084664)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250111(CHEMBL4084664)
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)