BDBM50248211 CHEMBL526305::N-cyclopropyl-N-((1s,4R)-4-cyclopropyl-4-hydroxycyclohexyl)-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide::N-cyclopropyl-N-(cis-4-cyclopropyl-4-hydroxycyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide

SMILES C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@](O)(CC1)C1CC1)C(F)(F)F

InChI Key InChIKey=SWXZIRVTPISJMP-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50248211   

LigandPNGBDBM50248211(N-cyclopropyl-N-((1s,4R)-4-cyclopropyl-4-hydroxycy...)
Affinity DataIC50: 52nMAssay Description:Inhibition of human recombinant full length 11beta-HSD1 expressed in HEK293 cells assessed as inhibition of conversion of [3H]cortisone to [3H]cortis...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50248211(N-cyclopropyl-N-((1s,4R)-4-cyclopropyl-4-hydroxycy...)
Affinity DataIC50: 121nMAssay Description:Inhibition of human recombinant full length 11beta-HSD1 expressed in HEK293 cells assessed as inhibition of conversion of [3H]cortisone to [3H]cortis...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50248211(N-cyclopropyl-N-((1s,4R)-4-cyclopropyl-4-hydroxycy...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant full length 11beta-HSD1 expressed in human adipocytes assessed as inhibition of conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50248211(N-cyclopropyl-N-((1s,4R)-4-cyclopropyl-4-hydroxycy...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human full length 11beta-HSD1 assessed as inhibition of conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50248211(N-cyclopropyl-N-((1s,4R)-4-cyclopropyl-4-hydroxycy...)
Affinity DataIC50: 14nMAssay Description:Inhibition of FLAG-tagged full length human 11beta-HSD1 expressed in baculovirus-infected Trichoplusia ni Hi5 cells assessed as reduction of [3H]cort...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50248211(N-cyclopropyl-N-((1s,4R)-4-cyclopropyl-4-hydroxycy...)
Affinity DataIC50: 52nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in absence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50248211(N-cyclopropyl-N-((1s,4R)-4-cyclopropyl-4-hydroxycy...)
Affinity DataIC50: 121nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in presence of 3% human serum albuminMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50248211(N-cyclopropyl-N-((1s,4R)-4-cyclopropyl-4-hydroxycy...)
Affinity DataIC50: 244nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed