BDBM50239952 CHEMBL4081997

SMILES NCCNS(=O)(=O)c1ccc(cc1)-c1ccc(CSc2nc3CCCc3c(=O)[nH]2)cc1

InChI Key InChIKey=YDCCHZDGDMSTQT-UHFFFAOYSA-N

Data  1 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50239952   

TargetMatrix metalloproteinase-14(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP14 using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition measured immediately by fluo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of MMP13 (unknown origin)-mediated type-2 collagen cleavage assessed as increase in intact collagen after 24 hrs by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMacrophage metalloelastase(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: 467nMAssay Description:Inhibition of recombinant human MMP12 expressed in baculovirus expression system using Mca-Pro-LeuGly-Leu-Dpa-Ala-Arg-NH2 as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of full length recombinant human MMP13 expressed in mouse NSO cells using fTHP-15 as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: 730nMAssay Description:Inhibition of recombinant human MMP2 expressed in mouse NSO cells using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeutrophil collagenase(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: 600nMAssay Description:Inhibition of MMP8 (unknown origin) using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition measured immediately by fluore...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MMP9 (unknown origin) using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition measured immediately by fluore...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human MMP1 expressed in mouse NSO cells using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant human MMP13 using APMA and fTHP-15(FAM) as substrate preincubated for 30 mins followed by substrate addition by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target72 kDa type IV collagenase(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: 730nMAssay Description:Inhibition of MMP-2 (unknown origin) using fTHP-15(FAM) as substrateMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNeutrophil collagenase(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: 600nMAssay Description:Inhibition of MMP-8 (unknown origin) using fTHP-15(FAM) as substrateMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCollagen alpha-1(II) chain(Human)
Graz University of Technology

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of Collagen-II-alpha 1 (unknown origin) incubated for 22 hrs by Coomassie blue staining based SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCollagenase 3(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataKi:  14nMAssay Description:Inhibition of full length recombinant human MMP13 expressed in mouse NSO cells using varying levels of fTHP-15 as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed