BDBM50239488 CHEMBL4092338::US10329302, Example 26::US10793579, Example 26::US11702424, Example 26

SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O

InChI Key InChIKey=YLJNGHKLWZPDSX-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50239488   

LigandPNGBDBM50239488(CHEMBL4092338 | US10329302, Example 26 | US1079357...)
Affinity DataIC50: 133nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239488(CHEMBL4092338 | US10329302, Example 26 | US1079357...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239488(CHEMBL4092338 | US10329302, Example 26 | US1079357...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50239488(CHEMBL4092338 | US10329302, Example 26 | US1079357...)
Affinity DataIC50: 4.60nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50239488(CHEMBL4092338 | US10329302, Example 26 | US1079357...)
Affinity DataIC50: 4.60nMAssay Description:Protocol B: To begin the assay, 45 μL of reaction mixture containing 20 mM HEPES pH=7.5, 5 mM MgCl2, 0.0025% Brij-35, 600 μM ATP, 228 μ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50239488(CHEMBL4092338 | US10329302, Example 26 | US1079357...)
Affinity DataIC50: 4.60nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50239488(CHEMBL4092338 | US10329302, Example 26 | US1079357...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of full-length IRAK4 (unknown origin) in presence of ATP by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239488(CHEMBL4092338 | US10329302, Example 26 | US1079357...)
Affinity DataIC50: 133nMAssay Description:Inhibition of IRAK4 in human PBMC cells assessed as reduction in R848-stimulated TNF-alpha productionMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)