BDBM50236362 CHEMBL429743::N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide::N-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide

SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC

InChI Key InChIKey=WUBFAXNVDMCVIO-UHFFFAOYSA-N

Data  20 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50236362   

TargetAurora kinase A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 371nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 38nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 20nMAssay Description:Inhibition of c-FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 55nMAssay Description:Inhibition of FGFR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 18nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 38nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 580nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 450nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 18nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed