BDBM50235034 CHEMBL4064277

SMILES FC(F)(F)c1ccc(N2CCCCC2)c(NC(=O)c2ccncc2)c1

InChI Key InChIKey=DWFGGOFPIISJIT-UHFFFAOYSA-N

Data  1 KI  14 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50235034   

TargetDual specificity protein kinase CLK1(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CLK1 using myelin basic protein as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Bordeaux

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 960nMAssay Description:Inhibition of human VEGFR2 (unknown origin) incubated for 1 hrs in presence of ATP by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DYRK3 using RRRFRPASPLRGPPK as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DYRK2 using RRRFRPASPLRGPPK as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DYRK1B using RRRFRPASPLRGPPK as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DYRK1A using RRRFRPASPLRGPPK as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDual specificity protein kinase CLK4(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CLK4 using myelin basic protein as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDual specificity protein kinase CLK3(Homo sapiens)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CLK3 using myelin basic protein as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDual specificity protein kinase CLK2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CLK2 using myelin basic protein as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSRSF protein kinase 3(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 27nMAssay Description:Inhibition of human SRPK3 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSRSF protein kinase 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataEC50:  2.56E+3nMAssay Description:Inhibition of N-terminal nLuc-fused SRPK2 (unknown origin) transfected in lysed HEK293T cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSRSF protein kinase 3(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataEC50:  398nMAssay Description:Inhibition of N-terminal nLuc-fused SRPK3 (unknown origin) transfected in intact HEK293T cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSRSF protein kinase 1(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataEC50:  2.36E+3nMAssay Description:Inhibition of C-terminal nLuc-fused SRPK1 (unknown origin) transfected in intact HEK293T cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetSRSF protein kinase 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSRSF protein kinase 1(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 83nMAssay Description:Inhibition of human SRPK1 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetSRSF protein kinase 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of SRPK2 (unknown origin) incubated for 10 mins in presence of ATP by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSRSF protein kinase 1(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataIC50: 890nMAssay Description:Inhibition of SRPK1 (unknown origin) using SRSF1 Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRSRSRSRSRSNSRSRSY-OH) as substrate incubated for 10 mins in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetSRSF protein kinase 1(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235034(CHEMBL4064277)
Affinity DataKi:  890nMAssay Description:Inhibition of mouse His6-tagged SRPK1 expressed in Escherichia coli(BL21)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)