BDBM50234916 CHEMBL4098188

SMILES O=C(CCc1nc2ccccc2c(=O)[nH]1)Nc1ccc(cc1)C(=O)Nc1cccc2cccnc12

InChI Key InChIKey=HILQRGHXDPSDBM-UHFFFAOYSA-N

Data  18 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50234916   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 0.204nMAssay Description:Inhibition of recombinant human N-terminal His-GST-tagged TNKS2 (849 to 1166 residues) expressed in baculovirus infected Sf9 cells using biotinylated...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) measured after 15 hrs in presence of NAD+ by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PARP10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PARP16 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 3.98E+4nMAssay Description:Inhibition of PARP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP4(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 6.92E+4nMAssay Description:Inhibition of PARP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged TNKS1 (1001 to 1327 residues) expressed in baculovirus infected sf9 cells using TACS-Sapphire a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PARP1 expressed in Baculovirus infected Sf9 cells using TACS-Sapphire as substrate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PARP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human N-terminal His-GST-tagged TNKS2 (849 to 1166 residues) expressed in baculovirus infected Sf9 cells using biotinylated...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP12(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PARP12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells measured after 1 hr by ch...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 8.32E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PARP1 expressed in Baculovirus infected Sf9 cells using TACS-Sapphire as substrate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 6.92E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells measured after 1 hr by ch...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP4(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 6.90E+4nMAssay Description:Inhibition of PARP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged TNKS1 (1001 to 1327 residues) expressed in baculovirus infected sf9 cells using TACS-Sapphire a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP15(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PARP15 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed