BDBM50218734 8-chloro-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one::8-chloro-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one::CHEMBL396034::Chk1_8

SMILES Clc1ccc2Nc3ccccc3C(=O)Nc2c1

InChI Key InChIKey=YVWNDABPZGGQFE-UHFFFAOYSA-N

Data  2 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50218734   

LigandPNGBDBM50218734(CHEMBL396034 | Chk1_8 | 8-chloro-5H-dibenzo[b,e][1...)
Affinity DataIC50: 1.70E+4nMAssay Description:ChemBL affinity - Published Abbott papersMore data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50218734(CHEMBL396034 | Chk1_8 | 8-chloro-5H-dibenzo[b,e][1...)
Affinity DataIC50: 1.72E+4nMAssay Description:Abbott Kinase Enzymatics_CHK1/289 CDC25c - IC50(uM) (IC50)More data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50218734(CHEMBL396034 | Chk1_8 | 8-chloro-5H-dibenzo[b,e][1...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human recombinant Chk1More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50218734(CHEMBL396034 | Chk1_8 | 8-chloro-5H-dibenzo[b,e][1...)
Affinity DataKi:  1.58E+4nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50218734(CHEMBL396034 | Chk1_8 | 8-chloro-5H-dibenzo[b,e][1...)
Affinity DataKi:  1.72E+4nMAssay Description:33P-Radiometric_Method1More data for this Ligand-Target Pair
In DepthDetails
D3R
PDB3D3D Structure (crystal)